Effect of Captopril on Acetylcholine-lnduced Relaxation in the Presence of Nitroglycerin Tolerance in Isolated Rabbit Aorta

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Abstract

We investigated the effects of angiotensin converting enzyme inhibitors on acetylcholine-induced endothelium-dependent vasodilation in the presence of nitroglycerin tolerance in rings of rabbit thoracic aorta mounted in tissue baths and precontracted with 10<sup>–6</sup> M norepinephrine. The vasorelaxant effects of acetylcholine were measured before and after 1 h treatment with 5 × 10<sup>–4</sup> M nitroglycerin. The acetylcholine dose-response curve shifted to the right after the induction of nitroglycerin tolerance. Pretreatment with captopril (a sulfhydryl angiotensin converting enzyme inhibitor), but not with M-1 (a metabolite of delapril and a nonsulfhydryl angiotensin converting enzyme inhibitor) restored acetylcholine-induced relaxation. Pretreatment with N-acetylcysteine also restored reduced acetylcholine-induced relaxation. These results suggest that the sulfhydryl group plays a major role in restoration of reduced acetylcholine-induced vasodilation in the presence of nitroglycerin tolerance.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1995

Publication date (Print): 1995

Publication date (Electronic): 24 September 2008

Volume: 32

Issue: 5

Pages: 347-352

Affiliations

^aThird Department of Internal Medicine, Ohashi Hospital, Toho University School of Medicine, Meguro-ku, Tokyo, and ^bCardiology Division, National Medical Center Hospital, Shinjuku-ku, Tokyo, Japan

Article

Publisher ID: 159109 Other ID: J Vasc Res 1995;32:347–352

DOI: 10.1159/000159109

PubMed ID: 7578803

SO-VID: 0d9811ed-43d5-4f3c-9ba2-e4bf9a76a335

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 29 September 1994

Date accepted : 11 May 1995

Page count

Pages: 6

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