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      Effect of Captopril on Acetylcholine-lnduced Relaxation in the Presence of Nitroglycerin Tolerance in Isolated Rabbit Aorta

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          We investigated the effects of angiotensin converting enzyme inhibitors on acetylcholine-induced endothelium-dependent vasodilation in the presence of nitroglycerin tolerance in rings of rabbit thoracic aorta mounted in tissue baths and precontracted with 10<sup>–6</sup> M norepinephrine. The vasorelaxant effects of acetylcholine were measured before and after 1 h treatment with 5 × 10<sup>–4</sup> M nitroglycerin. The acetylcholine dose-response curve shifted to the right after the induction of nitroglycerin tolerance. Pretreatment with captopril (a sulfhydryl angiotensin converting enzyme inhibitor), but not with M-1 (a metabolite of delapril and a nonsulfhydryl angiotensin converting enzyme inhibitor) restored acetylcholine-induced relaxation. Pretreatment with N-acetylcysteine also restored reduced acetylcholine-induced relaxation. These results suggest that the sulfhydryl group plays a major role in restoration of reduced acetylcholine-induced vasodilation in the presence of nitroglycerin tolerance.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          24 September 2008
          : 32
          : 5
          : 347-352
          aThird Department of Internal Medicine, Ohashi Hospital, Toho University School of Medicine, Meguro-ku, Tokyo, and bCardiology Division, National Medical Center Hospital, Shinjuku-ku, Tokyo, Japan
          159109 J Vasc Res 1995;32:347–352
          © 1995 S. Karger AG, Basel

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          Pages: 6
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