Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

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Abstract

Background

Acupuncture has been used as a common therapeutic tool in many disorders including anxiety and depression. Serotonin transporter (SERT) plays an important role in the pathology of anxiety and other mood disorders. The aim of this study was to evaluate the effects of acupuncture on lipopolysaccharide (LPS)-induced anxiety-like behaviors and SERT in the dorsal raphe nuclei (DRN).

Methods

Rats were given acupuncture at ST41 ( Jiexi), LI11 ( Quchi) or SI3 ( Houxi) acupoint in LPS-treated rats. Anxiety-like behaviors of elevated plus maze (EPM) and open field test (OFT) were measured and expressions of SERT and/or c-Fos were also examined in the DRN using immunohistochemistry.

Results

The results showed that 1) acupuncture at ST41 acupoint, but neither LI11 nor SI3, significantly attenuated LPS-induced anxiety-like behaviors in EPM and OFT, 2) acupuncture at ST41 decreased SERT expression increased by LPS in the DRN.

Conclusions

Our results suggest that acupuncture can ameliorate anxiety-like behaviors, possibly through regulation of SERT in the DRN.

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Most cited references 40

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Structure and function of the brain serotonin system.

Thomas Jacobs, E Azmitia (1991)

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The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication.

Ronald C Kessler, Wai Tat Chiu, Robert Jin … (2006)

Only limited information exists about the epidemiology of DSM-IV panic attacks (PAs) and panic disorder (PD). To present nationally representative data about the epidemiology of PAs and PD with or without agoraphobia (AG) on the basis of the US National Comorbidity Survey Replication findings. Nationally representative face-to-face household survey conducted using the fully structured World Health Organization Composite International Diagnostic Interview. English-speaking respondents (N=9282) 18 years or older. Respondents who met DSM-IV lifetime criteria for PAs and PD with and without AG. Lifetime prevalence estimates are 22.7% for isolated panic without AG (PA only), 0.8% for PA with AG without PD (PA-AG), 3.7% for PD without AG (PD only), and 1.1% for PD with AG (PD-AG). Persistence, lifetime number of attacks, and number of years with attacks increase monotonically across these 4 subgroups. All 4 subgroups are significantly comorbid with other lifetime DSM-IV disorders, with the highest odds for PD-AG and the lowest for PA only. Scores on the Panic Disorder Severity Scale are also highest for PD-AG (86.3% moderate or severe) and lowest for PA only (6.7% moderate or severe). Agoraphobia is associated with substantial severity, impairment, and comorbidity. Lifetime treatment is high (from 96.1% for PD-AG to 61.1% for PA only), but 12-month treatment meeting published treatment guidelines is low (from 54.9% for PD-AG to 18.2% for PA only). Although the major societal burden of panic is caused by PD and PA-AG, isolated PAs also have high prevalence and meaningful role impairment.

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Endotoxin produces a depressive-like episode in rats.

Raz Yirmiya (1996)

Activation of the immune system produces psychological and physiological effects, which resemble the characteristics of depression. The present study was designed to investigate further, in rats, the similarity between the behavioral effects of immune activation and a model of depression in animals. Reduction in the preference for and consumption of saccharin solutions and suppression of sexual behavior were used as models of one essential feature of depression, the inability to experience pleasure (anhedonia). Other measures testing this model were the reduction in food consumption, body weight, locomotor activity, and social interaction. It was found that systemic injection of lipopolysaccharide (endotoxin), which is a potent activator of the immune system, significantly decreased saccharin preference in fluid-deprived rats. Lipopolysaccharide (LPS) also decreased free consumption of saccharin, but not water, in non-deprived rats. Several indices of male sexual behavior were significantly suppressed following LPS administration. Chronic, but not acute, treatment with the tricyclic antidepressant imipramine abolished the suppressive effect of LPS on saccharin preference. Moreover, chronic, but not acute, treatment with imipramine also reduced and facilitated the recovery from the suppressive effects of LPS on food consumption, body weight, social interaction and activity in the open-field test. The results suggest that activation of the immune system in rats produces anhedonia and other depressive-like symptoms, which can be attenuated or completely blocked by chronic treatment with an antidepressant drug.

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Author and article information

Contributors

Tae Young Yang: tyerisio92@naver.com

Eun Young Jang: jangey80@gmail.com

Yeonhee Ryu: yhryu@kiom.re.kr

Gyu Won Lee: rosemary_001@naver.com

Eun Byeol Lee: galaxy0317@naver.com

Suchan Chang: c64111915@gmail.com

Jong Han Lee: juju0101@naver.com

Jin Suk Koo: kimkoo1114@andong.ac.kr

Chae Ha Yang: chayng@dhu.ac.kr

Hee Young Kim: +82-53-770-2256 , hykim@dhu.ac.kr

Journal

Journal ID (nlm-ta): BMC Complement Altern Med

Journal ID (iso-abbrev): BMC Complement Altern Med

Title: BMC Complementary and Alternative Medicine

Publisher: BioMed Central (London )

ISSN (Electronic): 1472-6882

Publication date (Electronic): 11 December 2017

Publication date PMC-release: 11 December 2017

Publication date Collection: 2017

Volume: 17

Electronic Location Identifier: 528

Affiliations

[1 ]ISNI 0000 0004 1790 9085, GRID grid.411942.b, College of Korean Medicine, , Daegu Haany University, ; Daegu, 42158 South Korea

[2 ]ISNI 0000 0000 8749 5149, GRID grid.418980.c, Korean Medicine Fundamental Research Division, Korea Institute of Oriental Medicine, ; Daejeon, 34054 South Korea

[3 ]ISNI 0000 0001 2299 2686, GRID grid.252211.7, Department of Bioresource Science, , Andong National University, ; Andong, 36729 South Korea

[4 ]ISNI 0000 0004 1790 9085, GRID grid.411942.b, Department of Physiology, College of Korean Medicine, , Daegu Haany University, ; Daegu, 42158 South Korea

Article

Publisher ID: 2039

DOI: 10.1186/s12906-017-2039-y

PMC ID: 5725650

SO-VID: 0d9c2672-9f51-4b64-91ce-322b32ebb91f

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 30 August 2017

Date accepted : 29 November 2017

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100003718, Korea Institute of Oriental Medicine;

Award ID: Y15102 and K16070

Award Recipient : Hee Young Kim

Funded by: FundRef http://dx.doi.org/10.13039/501100003725, National Research Foundation of Korea;

Award ID: 2016R1D1A1B03935206

Award ID: 2017R1E1A2A01079599

Award Recipient : Eun Young Jang Hee Young Kim

Custom metadata

ScienceOpen disciplines: Complementary & Alternative medicine

Keywords: acupuncture,anxiety,dorsal raphe nucleus,lps,serotonin transporter

Data availability:

ScienceOpen disciplines: Complementary & Alternative medicine

Keywords: acupuncture, anxiety, dorsal raphe nucleus, lps, serotonin transporter

Effect of acupuncture on Lipopolysaccharide-induced anxiety-like behavioral changes: involvement of serotonin system in dorsal Raphe nucleus

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Abstract

Background

Methods

Results

Conclusions

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The International Journal of Person Centered Medicine

Most cited references 40

Structure and function of the brain serotonin system.

The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication.

Endotoxin produces a depressive-like episode in rats.

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