Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals

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Abstract

The present study was undertaken to evaluate the anxiolytic and anti-depressant activity of Sarasvata choorna. The anxiolytic activity was evaluated in elevated plus maze (EPM) and the anti-depressant activity was evaluated in forced swimming test (FST). The efficacy of Sarasvata choorna was compared with the standard anti-anxiety (diazepam 2 mg/kg) and anti-depressant (imipramine – 5 mg/kg) drugs. It was observed that Sarasvata choorna at the dose of 390 mg/kg is as effective as standard drugs used in anti-anxiety and anti-depressant activities in mice by increasing time spent in open arm and entries to open arm in EPM model and increasing immobility time in FST model respectively. Hence it can be concluded that Sarasvata choorna may be used as a potent therapeutic agent in treating anxiety and depressive disorders.

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The use of a plus-maze to measure anxiety in the mouse.

R Lister (1987)

To investigate whether an elevated plus-maze consisting of two open and two closed arms could be used as a model of anxiety in the mouse, NIH Swiss mice were tested in the apparatus immediately after a holeboard test. Factor analysis of data from undrugged animals tested in the holeboard and plus-maze yielded three orthogonal factors interpreted as assessing anxiety, directed exploration and locomotion. Anxiolytic drugs (chlordiazepoxide, sodium pentobarbital and ethanol) increased the proportion of time spent on the open arms, and anxiogenic drugs (FG 7142, caffeine and picrotoxin) reduced this measure. Amphetamine and imipramine failed to alter the indices of anxiety. The anxiolytic effect of chlordiazepoxide was reduced in mice that had previously experienced the plus-maze in an undrugged state. Testing animals in the holeboard immediately before the plus-maze test significantly elevated both the percentage of time spent on the open arms and the total number of arm entries, but did not affect the behavioral response to chlordiazepoxide. The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.

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Bacopa monniera, a reputed nootropic plant: an overview.

A. Russo, F Borrelli (2005)

Bacopa monniera (BM), a traditional Ayurvedic medicine, used for centuries as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and antiepileptic agent. The plant, plant extract and isolated bacosides (the major active principles) have been extensively investigated in several laboratories for their neuropharmacological effects and a number of reports are available confirming their nootropic action. In addition, researchers have evaluated the anti-inflammatory, cardiotonic and other pharmacological effects of BM preparations/extracts. Therefore, in view of the important activities performed by this plant, investigation must be continued in the recently observed actions described in this paper. Moreover, other clinical studies have to be encouraged, also to evidence any side effects and possible interactions between this herbal medicine and synthetic drugs.

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Author and article information

Journal

Journal ID (nlm-ta): Ayu

Journal ID (iso-abbrev): Ayu

Journal ID (publisher-id): Ayu

Title: Ayu

Publisher: Medknow Publications & Media Pvt Ltd (India )

ISSN (Print): 0974-8520

ISSN (Electronic): 0976-9382

Publication date (Print): Oct-Dec 2011

Volume: 32

Issue: 4

Pages: 590-593

Affiliations

[1 ]Lecturer, Department of Kaya Chikitsa, Guru Nanak Ayurvedic Medical College and Hospital, Muktsar, Punjab, India

[2 ]Research Assistant, Pharmacology Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

[3 ]Director, Research and Development, SDM Research Centre for Ayurveda and Allied Sciences, Udupi, Karnataka, India

[4 ]Associate Professor and I/C Head, Department of Panchakarma, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Author notes

Address for correspondence: Dr. Kshama Gupta, Lecturer, Departmentt of Kaya Chikitsa, Guru Nanak Ayurvedic Medical College and Hospital, Near Ajit Cinema Barkandi Road, Muktsar, Punjab 152026, India. E-mail: drkshamagupta@ 123456gmail.com

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Publisher ID: Ayu-32-590

DOI: 10.4103/0974-8520.96139

PMC ID: 3361941

PubMed ID: 22661860

SO-VID: 0d9f7da4-eb44-4258-ac8d-75526ed2b38b

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This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Anti-anxiety and anti-depressant activities of Sarasvata choorna in experimental animals

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The International Journal of Person Centered Medicine

Most cited references 23

The use of a plus-maze to measure anxiety in the mouse.

The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Bacopa monniera, a reputed nootropic plant: an overview.

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