Curcumin attenuates the scurfy-induced immune disorder, a model of IPEX syndrome, with inhibiting Th1/Th2/Th17 responses in mice.

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Abstract

Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) is a lethal autoimmune disease caused by mutations in the Foxp3 gene scurfin (scurfy). Immunosuppressive therapy for IPEX patients has been generally ineffective and has caused severe side effects, however curcumin has shown immune regulation properties for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel diseases without side effects.

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Journal

Journal ID (iso-abbrev): Phytomedicine

Title: Phytomedicine : international journal of phytotherapy and phytopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1618-095X

ISSN (Print): 0944-7113

Publication date (Electronic): Sep 15 2017

Volume: 33

Affiliations

[1 ] Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, #1 Hoegi-Dong, Dongdaemoon-gu, Seoul, Republic of Korea; National Development Institute of Korean Medicine, Gyeongsan, Republic of Korea.

[2 ] Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, Republic of Korea.

[3 ] Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, #1 Hoegi-Dong, Dongdaemoon-gu, Seoul, Republic of Korea.

[4 ] Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, #1 Hoegi-Dong, Dongdaemoon-gu, Seoul, Republic of Korea. Electronic address: hbae@khu.ac.kr.

Article

Publisher Item ID: S0944-7113(17)30017-X

DOI: 10.1016/j.phymed.2017.01.008

PubMed ID: 28887914

SO-VID: 0d9fb30c-f132-41a4-b073-273c9d13d277

History

Keywords: T cell,Curcumin,IPEX,Scurfy,Tumeric

Data availability:

Keywords: T cell, Curcumin, IPEX, Scurfy, Tumeric

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