FGF/FGFR signaling in health and disease

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Abstract

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

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Author and article information

Contributors

Yangli Xie: xieyangli841015@163.com

Huabing Qi: hbqi3@163.com

Lin Chen:

ORCID: http://orcid.org/0000-0001-7764-9412

linchen70@163.com

Journal

Journal ID (nlm-ta): Signal Transduct Target Ther

Journal ID (iso-abbrev): Signal Transduct Target Ther

Title: Signal Transduction and Targeted Therapy

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 2095-9907

ISSN (Electronic): 2059-3635

Publication date (Electronic): 2 September 2020

Publication date PMC-release: 2 September 2020

Publication date Collection: 2020

Volume: 5

Electronic Location Identifier: 181

Affiliations

[1 ]GRID grid.414048.d, ISNI 0000 0004 1799 2720, Desartment of Wound Repair and Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, , Army Medical University, ; Chongqing, China

[2 ]GRID grid.264763.2, ISNI 0000 0001 2112 019X, Department of Biomedical Sciences, , Texas A&M University College of Dentistry, ; Dallas, TX 75246 USA

Author information

Shuo Huang http://orcid.org/0000-0001-9495-4339

Lin Chen http://orcid.org/0000-0001-7764-9412

Article

Publisher ID: 222

DOI: 10.1038/s41392-020-00222-7

PMC ID: 7468161

PubMed ID: 32879300

SO-VID: 0da18e12-3773-4306-bf62-ce87cd761cf9

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 1 April 2020

Date revision received : 28 May 2020

Date accepted : 15 June 2020

Funding

Funded by: The National Key Research and Development Program of China (2018YFA0800802), National Natural Science Foundation of China (81530071, 81772306, 81721001, 81991513), Innovative Research Team in University (IRT1216) and Key research and development projects of science and technology innovation of social undertakings and people’s livelihood security in Chongqing (cstc2017shms-zdyfX0027).