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      Brainstem auditory evoked potentials in children with autism spectrum disorder ☆☆ Translated title: Potenciais evocados auditivos de tronco encefálico em crianças com transtorno do espectro do autismo

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          Abstract

          Objectives

          This study aimed to analyze the neural encoding of verbal and nonverbal stimuli in individuals with autism spectrum disorder using brainstem auditory evoked potentials.

          Methodology

          Thirty individuals between 7 and 12 years of age and of both genders participated in this study. Fifteen were diagnosed with autism spectrum disorder, and 15 had typical development. All subjects had normal hearing and no other impairments. An electrophysiological hearing assessment was performed using brainstem auditory evoked potentials with click and speech stimuli.

          Results

          In the brainstem auditory evoked potentials with click stimuli, the mean wave I latency was longer for the right ear in both groups, and interpeak intervals III–V were greater for the individuals with autism spectrum disorder. For brainstem auditory evoked potentials with speech stimuli, wave V latency was shorter in individuals with autism spectrum disorder.

          Conclusion

          These data suggest that individuals with autism spectrum disorder may have a dysfunction of the central auditory nervous system for nonverbal stimuli and faster neural encoding of the initial part of the verbal stimulus, suggesting hypersensitivity to complex sounds such as speech.

          Resumo

          Objetivos

          Este estudo visou analisar a codificação neural de estímulos verbais e não verbais em indivíduos com transtorno do espectro do autismo com o uso de potenciais evocados auditivos de tronco encefálico.

          Metodologia

          Participaram 30 indivíduos entre sete e 12 anos e de ambos os sexos; 15 foram diagnosticados com transtorno do espectro do autismo e 15 apresentaram desenvolvimento típico. Todos os indivíduos apresentaram audição normal e nenhuma outra alteração. Foi feita uma avaliação eletrofisiológica da audição com o uso dos potenciais evocados auditivos de tronco encefálico com estímulos de clique e fala.

          Resultados

          Nos potenciais evocados auditivos de tronco encefálico com estímulos de clique, a média do valor de latência da onda I foi maior para o ouvido direito nos dois grupos e os intervalos interpicos III-V foram maiores para os indivíduos com transtorno do espectro do autismo. Para os potenciais evocados auditivos de tronco encefálico com estímulos de fala, a latência da onda V foi menor nos indivíduos com transtorno do espectro do autismo.

          Conclusão

          Nossos dados sugerem que os indivíduos com transtorno do espectro do autismo podem ter uma disfunção do sistema nervoso auditivo central para estímulos não verbais e codificação neural mais rápida da parte inicial dos estímulos verbais, o que sugere hipersensibilidade a sons complexos, como a fala.

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          Most cited references28

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          Autistic disturbances of affective contact

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            Auditory processing in autism spectrum disorder: a review.

            For individuals with autism spectrum disorder or 'ASD' the ability to accurately process and interpret auditory information is often difficult. Here we review behavioural, neurophysiological and imaging literature pertaining to this field with the aim of providing a comprehensive account of auditory processing in ASD, and thus an effective tool to aid further research. Literature was sourced from peer-reviewed journals published over the last two decades which best represent research conducted in these areas. Findings show substantial evidence for atypical processing of auditory information in ASD at behavioural and neural levels. Abnormalities are diverse, ranging from atypical perception of various low-level perceptual features (i.e. pitch, loudness) to processing of more complex auditory information such as prosody. Trends across studies suggest auditory processing impairments in ASD are most likely to present during processing of complex auditory information and are more severe for speech than for non-speech stimuli. The interpretation of these findings with respect to various cognitive accounts of ASD is discussed and suggestions offered for further research. Copyright © 2011 Elsevier Ltd. All rights reserved.
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              Abnormal cortical voice processing in autism.

              Impairments in social interaction are a key feature of autism and are associated with atypical social information processing. Here we report functional magnetic resonance imaging (fMRI) results showing that individuals with autism failed to activate superior temporal sulcus (STS) voice-selective regions in response to vocal sounds, whereas they showed a normal activation pattern in response to nonvocal sounds. These findings suggest abnormal cortical processing of socially relevant auditory information in autism.
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                Author and article information

                Contributors
                Journal
                J Pediatr (Rio J)
                J Pediatr (Rio J)
                Jornal de Pediatria
                Elsevier
                0021-7557
                1678-4782
                22 February 2019
                May-Jun 2020
                22 February 2019
                : 96
                : 3
                : 386-392
                Affiliations
                [0005]Universidade de São Paulo (USP), Faculdade de Medicina (FM), Departamento de Terapia Física, Fonoaudiologia e Terapia Ocupacional, São Paulo, SP, Brazil
                Author notes
                [* ]Corresponding author. marikeikokamita@ 123456gmail.com
                Article
                S0021-7557(18)30863-5
                10.1016/j.jped.2018.12.010
                9432277
                30802422
                0da5dfa0-9149-47f5-b364-6acea689b473
                © 2019 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 8 August 2018
                : 13 December 2018
                Categories
                Original Article

                autistic disorder,electrophysiology,auditory evoked potentials,transtorno autista,eletrofisiologia,potenciais evocados auditivos

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