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      Skeletal and cardiac muscle pericytes: Functions and therapeutic potential

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          Abstract

          Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states, including fibrosis, heterotopic ossication and calcification, atherosclerosis, and tumor angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.

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          Author and article information

          Journal
          7905840
          6445
          Pharmacol Ther
          Pharmacol. Ther.
          Pharmacology & therapeutics
          0163-7258
          1879-016X
          2 December 2017
          02 September 2016
          March 2017
          12 December 2017
          : 171
          : 65-74
          Affiliations
          [a ]BHF Center for Vascular Regeneration and MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, UK
          [b ]Department of Trauma and Orthopaedic Surgery, The University of Edinburgh, Edinburgh, UK
          [c ]Reseach Laboratory of Electronics and Department of Biological Engineering, Massachusetts Institute of Technology, Boston, MA, USA
          [d ]Orthopedic Hospital Research Center, University of California, Los Angeles, CA, USA
          [e ]Division of Cardiology, Department of Medicine & Molecular Cell and Developmental Biology, and Eli and Edythe Broad Institute of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, CA, USA
          [f ]MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
          Author notes
          [* ]Correspondence to: A. Deb, Division of Cardiology, Department of Medicine & Molecular Cell & Developmental Biology, and Eli and Edythe Broad Institute of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine and College of Letters and Sciences, University of California, Los Angeles, CA 90095-7357, United States
          [** ]Correspondence to: N. C. Henderson, MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, Scotland EH16 4TJ, UK. Tel.: +44 131 242 6653
          Article
          PMC5726267 PMC5726267 5726267 nihpa923887
          10.1016/j.pharmthera.2016.09.005
          5726267
          27595928
          0db79300-bd8d-4bb3-8cee-44e8432e53b9
          History
          Categories
          Article

          Perivascular stem cell,Mesenchymal stem cell,PSC,MSC,Heart,Muscle

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