+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Exercise Tolerance of End-Stage Renal Disease Patients

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The purpose of this study was to evaluate the exercise tolerance of end-stage renal disease patients, and to examine pulmonary function and blood lactate as its possible limiting factors. Ten end-stage renal disease patients (age 30 ± 11) were tested at rest and in a subsequent graded treadmill test to exhaustion. Velocity was 4.8 km/h and the grade was incremented by 2.5% every 4 min. One minute of rest, used for blood sampling, separated successive stages. Pulmonary functions (FVC, FEV<sub>1</sub>) at rest were both 76% of predicted. Resting heart rate, systolic and diastolic blood pressures, and ventilatory equivalent values were higher than normal. At peak exercise, heart rate, oxygen uptake, oxygen pulse and blood lactic acid were lower than normally predicted for maximal exercise, while ventilatory equivalent and diastolic blood pressure were higher. Only six patients reached blood lactate levels beyond 4 mM· 1<sup>-1</sup> (onset of blood lactic acid), at which point they utilized 88 ± 5% of their respective peak V<sub>02</sub>. The results suggest that the low exercise tolerance demonstrated in end-stage renal disease patients is not limited by the somewhat compromised pulmonary capacity or by excessive blood lactate levels.

          Related collections

          Author and article information

          S. Karger AG
          11 December 2008
          : 57
          : 4
          : 424-427
          Department of Life Sciences and Sports Medicine, Zinman College of Physical Education, Wingate Institute, Netanya, Israel
          186307 Nephron 1991;57:424–427
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Original Paper


          Comment on this article