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      Natural and Melatonin-Stimulated Changes in the Circadian Rhythm of Prolactin Secretion in the Ewe during Seasonal Anestrus

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          Abstract

          The relations between the circadian rhythms of melatonin and prolactin, and the effect of melatonin infused into the third ventricle or the mediobasal hypo-thalamus (MBH) on prolactin secretion and dopamine (DA) release were studied in anestrous ewes under increasing daylength conditions. The decreased amplitude and duration of nocturnal melatonin secretion were accompanied with changes in the daily pattern of prolactin secretion. Marked peaks of prolactin occurred after sunrise and melatonin decreases in February, as well as significant evening or nocturnal peaks under long day conditions between April and July. Melatonin infused into the third ventricle evoked an abrupt increase in the concentration of prolactin after 30 min, and the enhanced prolactin level was significantly higher than during the control infusion (range from 204 ± 75 to 248 ± 48 ng/ml vs. 128 ± 68 to 149 ± 93 ng/ml, mean ± SD). The concentrations of DA in MBH perfusates decreased during perfusion of melatonin but to a degree similar to that noted in untreated ewes. These data suggest that short-term infusions of melatonin stimulate the secretion of prolactin in the ewe under increasing daylength conditions, and that this effect is not mediated by changes in DA release.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1997
          1997
          09 April 2008
          : 66
          : 5
          : 360-367
          Affiliations
          The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Science, Jabłonna, Poland
          Article
          127259 Neuroendocrinology 1997;66:360–367
          10.1159/000127259
          9387855
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Melatonin and Pineal Gland

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