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      The metastatic niche: adapting the foreign soil.

      Nature reviews. Cancer

      Bone Marrow Cells, pathology, blood supply, Neoplasms, Neoplasm Metastasis, Models, Biological, Humans

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          Abstract

          The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required.

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          Journal
          19308068
          10.1038/nrc2621
          3682494

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