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      Resonant Mie scattering (RMieS) correction applied to FTIR images of biological tissue samples.

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      The Analyst

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          Abstract

          Recently a resonant Mie scattering (RMieS) correction approach has been developed and demonstrated to be effective for removing the baseline distortions that compromise the raw data in individual spectra. In this paper RMieS correction is extended to FTIR images of a tissue section from biopsy of the human cervical transformation zone and a coronal tissue section of a Wistar rat brain and compared to the uncorrected images. It is shown that applying RMieS correction to FTIR images a) removes baseline distortions from the image spectra and thus reveals previously hidden information on spatial variation of chemical contents within the tissue and b) can lead to improved automatic tissue feature classification through multivariate cluster analysis.

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          Author and article information

          Journal
          Analyst
          The Analyst
          1364-5528
          0003-2654
          Jan 7 2012
          : 137
          : 1
          Affiliations
          [1 ] Centre for Biospectroscopy and School of Chemistry, Monash University, Clayton, Victoria, 3800, Australia.
          Article
          10.1039/c1an15628d
          22076587
          This journal is © The Royal Society of Chemistry 2012

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