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      Assessment of Renal Function in the Early Stages of Nephrotoxicity Induced by Iodinated Contrast Media

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          Abstract

          To determine whether there are early renal function parameters (RFP) which can be monitored to rapidly detect nephrotoxicity induced by contrast media (CM), we observed RFP in 16 patients with normal renal function before and after administration of CM. Forty-eight hours after diatrizoate meglumine administration, blood urea nitrogen (BUN) and serum creatinine (SCr) increased (p < 0.05). In all patients, acute tubular damage was revealed by early urinary RFP. Increases in levels of serum angiotensin-I-converting enzyme (ACE), β<sub>2</sub>-microglobulin (β<sub>2</sub>M) and urinary albumin (Alb) were associated with alterations in glomerular function. The changes in early RFP occurred earlier than those of BUN and SCr. The present study demonstrates that serum ACE, β<sub>2</sub>M, urinary Alb, γ-glutamyl-transpeptidase and N-acetyl-β- D-glucosidase are sensitive parameters for the early assessment of subclinical nephrotoxicity induced by CM.

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          Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome

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            Transient glomerular proteinuria, enzymuria, and nephrotoxic reaction induced by radiocontrast media.

            Contrast nephropathy is a recognized complication of arteriographic procedures; usually, it consists of a mild deterioration of renal function. In an attempt to understand better the mechanisms involved, we conducted a prospective study before and after arteriography that monitored the urinary elimination of high- and low-molecular weight proteins, the urinary activity of tubular enzymes, and renal clearances of 27 patients. We detected a noticeable and transient nonselective proteinuria of glomerular origin together with moderate signs of tubular damage and a stable renal function. We did not identify any risk factor. Contrast media may alter the disposition of charges along the glomerular filtering membrane in a way that promotes proteinuria; consequently, the massive flow of proteins may injure the tubular cells.
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              Increased urine angiotensin i converting enzyme activity in patients with upper urinary tract infection

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                1999
                October 1999
                22 September 1999
                : 83
                : 2
                : 122-125
                Affiliations
                Department of Medicine, Second Affiliated Hospital of Hunan Medical University, Changsha, Hunan, P.R. China
                Article
                45488 Nephron 1999;83:122–125
                10.1159/000045488
                10516490
                © 1999 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Tables: 2, References: 20, Pages: 4
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/45488
                Categories
                Original Paper

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