Assessment of Renal Function in the Early Stages of Nephrotoxicity Induced by Iodinated Contrast Media

Abstract

To determine whether there are early renal function parameters (RFP) which can be monitored to rapidly detect nephrotoxicity induced by contrast media (CM), we observed RFP in 16 patients with normal renal function before and after administration of CM. Forty-eight hours after diatrizoate meglumine administration, blood urea nitrogen (BUN) and serum creatinine (SCr) increased (p < 0.05). In all patients, acute tubular damage was revealed by early urinary RFP. Increases in levels of serum angiotensin-I-converting enzyme (ACE), β₂-microglobulin (β₂M) and urinary albumin (Alb) were associated with alterations in glomerular function. The changes in early RFP occurred earlier than those of BUN and SCr. The present study demonstrates that serum ACE, β₂M, urinary Alb, γ-glutamyl-transpeptidase and N-acetyl-β- D-glucosidase are sensitive parameters for the early assessment of subclinical nephrotoxicity induced by CM.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1999

Publication date (Print): October 1999

Publication date (Electronic): 22 September 1999

Volume: 83

Issue: 2

Pages: 122-125

Affiliations

Department of Medicine, Second Affiliated Hospital of Hunan Medical University, Changsha, Hunan, P.R. China

Article

Publisher ID: 45488 Other ID: Nephron 1999;83:122–125

DOI: 10.1159/000045488

PubMed ID: 10516490

Copyright statement: © 1999 S. Karger AG, Basel

License:

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Page count

Tables: 2, References: 20, Pages: 4

Product

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Categories

Subject: Original Paper