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      Effects of Chronic Nicotine Administration on RBC Velocity in Mesenteric Capillaries of the Rat

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      Journal of Vascular Research

      S. Karger AG

      MesenteryRBC velocity, Nicotine, Capillary flow

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          The purpose of this study was to determine the effects of chronic administration of nicotine on red blood cell (RBC) velocity in single capillaries of the mesentery. Ten male rats consumed an average of 2.38 mg nicotine/kg/day, an approximate ‘2 pack’ equivalent, in their drinking water for a period of 15–20 weeks. At the end of this time RBC velocity was measured in single capillaries of the mesentery. The data were compared to RBC velocities measured in a group of matched control rats. Red cell velocities in the control and nicotine groups averaged 1.22 ± 0.23 and 0.59 ± 0.10 mm/sec SEM, respectively. These values were significantly different (p < 0.01). It is concluded that chronic administration of nicotine to rats in levels equivalent to tobacco smoking reduces resting capillary blood flow in the mesenteric circulation as indicated by differences in erythrocyte velocity.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 14
          : 5
          : 318-324
          Department of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington, Ky.
          158138 Blood Vessels 1977;14:318–324
          © 1977 S. Karger AG, Basel

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          Page count
          Pages: 7


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