Effects of Chronic Nicotine Administration on RBC Velocity in Mesenteric Capillaries of the Rat

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Abstract

The purpose of this study was to determine the effects of chronic administration of nicotine on red blood cell (RBC) velocity in single capillaries of the mesentery. Ten male rats consumed an average of 2.38 mg nicotine/kg/day, an approximate ‘2 pack’ equivalent, in their drinking water for a period of 15–20 weeks. At the end of this time RBC velocity was measured in single capillaries of the mesentery. The data were compared to RBC velocities measured in a group of matched control rats. Red cell velocities in the control and nicotine groups averaged 1.22 ± 0.23 and 0.59 ± 0.10 mm/sec SEM, respectively. These values were significantly different (p < 0.01). It is concluded that chronic administration of nicotine to rats in levels equivalent to tobacco smoking reduces resting capillary blood flow in the mesenteric circulation as indicated by differences in erythrocyte velocity.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1977

Publication date (Print): 1977

Publication date (Electronic): 18 September 2008

Volume: 14

Issue: 5

Pages: 318-324

Affiliations

Department of Physiology and Biophysics, University of Kentucky College of Medicine, Lexington, Ky.

Article

Publisher ID: 158138 Other ID: Blood Vessels 1977;14:318–324

DOI: 10.1159/000158138

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