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Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.

Author(s): Isabel Cruz, R Docampo, E Robertis, Luciana R. Muniz, D M Esquivel

Publication date: 1978-08-31

Keywords: Electron Spin Resonance Spectroscopy, Methylphenazonium Methosulfate, pharmacology, Microsomes, metabolism, Mitochondria, Oxygen, Phenazines, Spectrum Analysis, Superoxides, Trypanosoma cruzi, growth & development, ultrastructure

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Abstract

A significant growth inhibition of Trypanosoma cruzi epimastigotes by phenazine methosulfate (PMS) was observed in Warren's medium. This toxic activity could be related to the following parameters: a) formation of phenazinium free radical, b) generation of superoxide anion in intact cells incubated with PMS, and c) PMS also increased significantly the rate of O2- generation in epimastigotes mitochondrial and microsomal fractions using NADH as electron donor.

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PubMed ID:: 31775

ScienceOpen disciplines: Chemistry

Keywords: Electron Spin Resonance Spectroscopy,Methylphenazonium Methosulfate,pharmacology,Microsomes,metabolism,Mitochondria,Oxygen,Phenazines,Spectrum Analysis,Superoxides,Trypanosoma cruzi,growth & development,ultrastructure

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ScienceOpen disciplines: Chemistry

Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes.

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