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      Myocardial Necrosis in the Rat: a Comparison between Isoprenaline, Orciprenaline, Salbutamol and Terbutaline

      ,

      Cardiology

      S. Karger AG

      Isoprenaline, Orciprenaline, Salbutamol, Terbutaline, Myocardial necrosis

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          Abstract

          The cardiotoxic effects of isoprenaline, orciprenaline, salbutamol, and terbutaline were compared in rats following daily subcutaneous administration for three consecutive days. Isoprenaline appeared to be the drug prone to induce myocardial necrosis, and salbutamol and terbutaline the least likely to do so. The data suggest that the more β<sub>1</sub>-stimulating a compound is, the more likely it is to causemyocardial necrosis.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 3
          : 174-180
          Affiliations
          Toxicology Laboratories, Astra Pharmaceuticals AB, Södertälje
          Article
          169631 Cardiology 1973;58:174–180
          10.1159/000169631
          4773536
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 7
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