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      Integrin Signaling

      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate.

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          Author and article information

          Journal
          Science
          American Association for the Advancement of Science (AAAS)
          00368075
          10959203
          August 1999
          : 285
          : 5430
          : 1028-1033
          Article
          10.1126/science.285.5430.1028
          10446041
          0e34502d-31cf-429a-9dbe-cce0ef590eaf
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