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      Effects of Gardenia jasminoides extracts on cognition and innate immune response in an adult Drosophila model of Alzheimer’s disease

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          Abstract

          Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer’s disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 December 2017
          : 15
          : 12
          : 899-904
          Affiliations
          1School of Life Science, Tsinghua University, Beijing 100084, China
          2Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China
          Author notes
          *Corresponding author: PENG I-Feng, Tel:+86-512-50720030; E-mail: ifengpeng@ 123456joekaibiotech.com .

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30005-0
          10.1016/S1875-5364(18)30005-0
          29329646
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Thousand Talents Program Research Park
          This work was supported by programs of Thousand Talents Program Research Park (Jiangsu, China), Provincial Innovation and Entrepreneurial Talent, Jiangsu, China (to I.F.P,) and Development of Society and Technology (Kunshan City, Jiangsu, China).

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