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      Pseudothrombocytopenia and IgA-Related Platelet Agglutinin in a Patient with IgA Nephritis

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          Abstract

          A 41-year-old female was evaluated for asymptomatic proteinuria and thrombocytopenia. The renal biopsy disclosed mild to moderate mesangial proliferation, and the immunohistology showed granular deposition of dominant IgA and C3 in the mesangium, which is consistent with IgA nephritis. Thrombocytopenia was EDTA-dependent pseudothrombocytopenia type 1. Heparinized blood restored the platelet count to normal. Serological examinations revealed that the platelet agglutinin was IgA, and the platelet clumping required both EDTA and IgA-related agglutinin. Thus, the present case adds the combination of IgA nephritis and pseudothrombocytopenia to the spectrum of the so-called thromborenal syndrome. In view of recent findings that platelet agglutinins belong to immunoglobulins or fractions, occurring frequently in a variety of immunologically abnormal situations, IgA-related agglutinin as seen in this patient may have more than a chance association with IgA nephritis.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 34
          : 3
          : 154-158
          Affiliations
          Third Department of Internal Medicine, School of Medicine, Akita University, Akita, Japan
          Article
          183001 Nephron 1983;34:154–158
          10.1159/000183001
          6877446
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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