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      Scratching the surface of skin development.

      Nature

      cytology, Stem Cells, growth & development, embryology, Skin, Sebaceous Glands, Regenerative Medicine, Humans, Hair Follicle, Hair, Animals

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          Abstract

          The epidermis and its appendages develop from a single layer of multipotent embryonic progenitor keratinocytes. Embryonic stem cells receive cues from their environment that instruct them to commit to a particular differentiation programme and generate a stratified epidermis, hair follicles or sebaceous glands. Exciting recent developments have focused on how adult skin epithelia maintain populations of stem cells for use in the natural cycles of hair follicle regeneration and for re-epithelialization in response to wounding.

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          Journal
          10.1038/nature05659
          2405926
          17314969

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