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      Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.

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          Abstract

          Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load.

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          Author and article information

          Journal
          Lancet Gastroenterol Hepatol
          The lancet. Gastroenterology & hepatology
          Elsevier BV
          2468-1253
          May 15 2017
          Affiliations
          [1 ] Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands.
          [2 ] Department of Gastroenterology and Hepatology, OLVG West, Amsterdam, Netherlands.
          [3 ] Department of Internal Medicine, Medical Center Zuiderzee, Lelystad, Netherlands.
          [4 ] Department of Gastroenterology and Hepatology, VU Medical Center, Amsterdam, Netherlands.
          [5 ] Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands; Department of Blood-borne Infections, Sanquin Blood Supply Foundation, Amsterdam, Netherlands.
          [6 ] Department of Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands.
          [7 ] Department of Virus Diagnostic Services, Sanquin Blood Supply Foundation, Amsterdam, Netherlands.
          [8 ] Department of Pathology, Academic Medical Center, Amsterdam, Netherlands.
          [9 ] Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands. Electronic address: h.w.reesink@amc.nl.
          Article
          S2468-1253(17)30083-3
          10.1016/S2468-1253(17)30083-3
          28522204

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