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      The effect of low dose gamma irradiation on the differentiation and maturation of monocyte derived dendritic cells.

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          Abstract

          The effects of gamma-irradiation on the differentiation of peripheral blood monocytes (PBM) into monocyte derived dendritic cells (MDC), their maturation, and subsequent ability to present antigen to T cells was studied. Undifferentiated MDC were more sensitive to gamma-irradiation induced apoptosis than mature MDC. Irradiation of immature MDC with 5 Gy of gamma-rays down regulated the expression of the costimulatory receptors CD80/CD86 and may compromise their ability to capture and present antigen. By contrast, gamma-Irradiation of mature MDC did not affect the expression of CD86/CD80, and HLA-DR. Gamma-irradiation increased the apoptosis of MDC; but did not affect the ability of mMDC to stimulate autologous MLR. T cell proliferative response in the MLR and in response to tetanus antigen was reduced when gamma-irradiated primary DC1 were used to either stimulate or present antigen to T cells.

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          Author and article information

          Journal
          J Gravit Physiol
          Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
          1077-9248
          1077-9248
          Jul 2004
          : 11
          : 2
          Affiliations
          [1 ] Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. jreuben@mdanderson.org
          16231453

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