• Record: found
  • Abstract: found
  • Article: found
Is Open Access

Anti-arthritic Activity of Dashanga Ghana (An Ayurvedic Compound Formulation) Against Freund's Adjuvant Induced Arthritis in Charles Foster Albino Rats

Read this article at

      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.



      Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases. There is a need to investigate the complete therapeutic potential of these herbals for providing newer and safer treatment options with minimum side effects. Considering this, a polyherbal Ayurvedic compound formulation ( Dashanga Ghana) has been studied in experimental animals to evaluate anti-arthritic activity.

      Materials and Methods:

      Dashanga Ghana has been prepared in the laboratory by following standard guidelines. Charles Foster albino rats were used to evaluate the activity through Freund's adjuvant induced arthritis model.

      Results and Conclusions:

      Dashanga Ghana is found to possess significant anti-arthritic activity. Further studies are required to identify and characterize exact active phyto-constituents and to elucidate the exact mechanism of action, which is responsible for the observed pharmacological profile.

      Related collections

      Most cited references 32

      • Record: found
      • Abstract: not found
      • Article: not found

      Plasma creatinine determination. A new and specific Jaffe reaction method.

       Jason Slot (1964)
        • Record: found
        • Abstract: not found
        • Article: not found

        Clinical guide to laboratory tests

          • Record: found
          • Abstract: found
          • Article: not found

          Review on some plants of Indian traditional medicine with antioxidant activity.

          A lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) named Rasayana proposed for their interesting antioxidant activities. Among the medicinal plants used in ayurvedic Rasayana for their therapeutic action, some of these have been throughly investigated. In the present paper seven plants (Emblica officinalis L., Curcuma longa L., Mangifera indica L., Momordica charantia L., Santalum album L., Swertia chirata Buch-Ham, Withania somnifera (L.) Dunal) are viewed for their historical, etymological, morphological, phytochemical and pharmacological aspects. The plants described contain antioxidant principles, that can explain and justify their use in traditional medicine in the past as well as the present. In order to identify the plants with antioxidant activity in Ayurveda, a formulation of some rasayanas with well defined antioxidant properties has been examinated. For this purpose, we have considered Sharma's work on the preparation MAK4, MAK5, MA631, MA 471, MA Raja's Cup, MA Student Rasayana, MA Ladies Rasayana.

            Author and article information

            Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
            [1 ]Drug Discovery Group, R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India
            [2 ]SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India
            Author notes
            Address for correspondence: Dr. Galib Ruknuddin, Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India. E-mail: galib14@
            Toxicol Int
            Toxicol Int
            Toxicology International
            Medknow Publications & Media Pvt Ltd (India )
            Jan-Apr 2015
            : 22
            : 1
            : 141-146
            26862275 4721162 TI-22-141 10.4103/0971-6580.172279
            Copyright: © Toxicology International

            This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.

            Original Article


            paw oedema, arthritis, ayurveda, dashanga ghana, freund's adjuvant


            Comment on this article