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      5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder

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      Psychiatry Research

      Elsevier BV

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          Abstract

          Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          Psychiatry Research
          Psychiatry Research
          Elsevier BV
          01651781
          August 2010
          August 2010
          : 178
          : 3
          : 556-558
          10.1016/j.psychres.2010.04.007
          20471101
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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