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TGF-β stimulation of EMT programs elicits non-genomic ER-α activity and anti-estrogen resistance in breast cancer cells
August 16 2017
August 21 2017
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Abstract
Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers.
Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of
ER-α; it also induces epithelial-mesenchymal transition (EMT) programs that promote
breast cancer dissemination, stemness, and chemoresistance. The impact of EMT programs
on nongenomic ER-α signaling remains unknown and was studied herein.