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      Analytical techniques in pharmaceutical analysis: A review

      , ,

      Arabian Journal of Chemistry

      Elsevier BV

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          Most cited references 167

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          Discovering high-affinity ligands for proteins: SAR by NMR.

          A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a protein are identified, optimized, and linked together to produce high-affinity ligands. The approach is called "SAR by NMR" because structure-activity relationships (SAR) are obtained from NMR. With this technique, compounds with nanomolar affinities for the FK506 binding protein were rapidly discovered by tethering two ligands with micromolar affinities. The method reduces the amount of chemical synthesis and time required for the discovery of high-affinity ligands and appears particularly useful in target-directed drug research.
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            FDA's policy statement for the development of new stereoisomeric drugs.

            (1991)
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              Flow injection analyses

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                Author and article information

                Journal
                Arabian Journal of Chemistry
                Arabian Journal of Chemistry
                Elsevier BV
                18785352
                February 2017
                February 2017
                : 10
                :
                : S1409-S1421
                Article
                10.1016/j.arabjc.2013.04.016
                © 2017

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