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      The glucose-regulated proteins: stress induction and clinical applications

      Trends in Biochemical Sciences

      Elsevier BV

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          Abstract

          A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.

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          Author and article information

          Journal
          Trends in Biochemical Sciences
          Trends in Biochemical Sciences
          Elsevier BV
          09680004
          August 2001
          August 2001
          : 26
          : 8
          : 504-510
          Article
          10.1016/S0968-0004(01)01908-9
          11504627
          © 2001

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