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A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum
(ER) is the induction of members of the glucose-regulated protein (Grp) family. The
induction of mammalian Grp proteins in response to ER stress involves a complex network
of regulators and novel mechanisms. The elucidation of Grp function and regulation
opens up new therapeutic approaches to diseases associated with ER stress and cancer.