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      What Has Been Trending in the Research of Polyhydroxyalkanoates? A Systematic Review

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          Abstract

          Over the past decades, enormous progress has been achieved with regard to research on environmentally friendly polymers. One of the most prominent families of such biopolymers are bacterially synthesized polyhydroxyalkanoates (PHAs) that have been known since the 1920s. However, only as recent as the 1990s have extensive studies sprung out exponentially in this matter. Since then, different areas of exploration of these intriguing materials have been uncovered. However, no systematic review of undertaken efforts has been conducted so far. Therefore, we have performed an unbiased search of up-to-date literature to reveal trending topics in the research of PHAs over the past three decades by data mining of 2,227 publications. This allowed us to identify eight past and current trends in this area. Our study provides a comprehensive review of these trends and speculates where PHA research is heading.

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          Most cited references115

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          Nano-biocomposites: Biodegradable polyester/nanoclay systems

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            Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate.

            Polyhydroxyalkanoates (PHAs) comprise a large class of polyesters that are synthesized by many bacteria as an intracellular carbon and energy compound. Analysis of isolated PHAs reveal interesting properties such as biodegradability and biocompatibility. Research was focused only recently on the application of PHA in implants, scaffolds in tissue engineering, or as drug carriers. Such applications require that PHA be produced at a constant and reproducible quality. To date this can be achieved best through bacterial production in continuous culture where growth conditions are kept constant (chemostat). Recently, it was found that PHA producing bacteria are able to grow simultaneously limited by carbon and nitrogen substrates. Thus, it became possible to produce PHA at high yields on toxic substrate and also control its composition accurately (tailor-made synthesis). Finally, applications of PHA in medicine are discussed.
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              Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production

              Sustainable biofuels, biomaterials, and fine chemicals production is a critical matter that research teams around the globe are focusing on nowadays. Polyhydroxyalkanoates represent one of the biomaterials of the future due to their physicochemical properties, biodegradability, and biocompatibility. Designing efficient and economic bioprocesses, combined with the respective social and environmental benefits, has brought together scientists from different backgrounds highlighting the multidisciplinary character of such a venture. In the current review, challenges and opportunities regarding polyhydroxyalkanoate production are presented and discussed, covering key steps of their overall production process by applying pure and mixed culture biotechnology, from raw bioprocess development to downstream processing.
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                Author and article information

                Contributors
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                10 September 2020
                2020
                : 8
                : 959
                Affiliations
                [1] 1Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences , Kraków, Poland
                [2] 2Institut für Molekulare Mikrobiologie und Biotechnologie, Westfälische Wilhelms-Universität Münster , Münster, Germany
                [3] 3Environmental Sciences Department, King Abdulaziz University , Jeddah, Saudi Arabia
                [4] 4Department of Product Technology and Ecology, Cracow University of Economics , Kraków, Poland
                [5] 5Department of Management Process, Cracow University of Economics , Kraków, Poland
                Author notes

                Edited by: Justyna Mozejko-Ciesielska, University of Warmia and Mazury in Olsztyn, Poland

                Reviewed by: Stanislav Obruca, Brno University of Technology, Czechia; Christopher John Brigham, Wentworth Institute of Technology, United States

                *Correspondence: Maciej Guzik ncguzik@ 123456cyfronet.pl

                This article was submitted to Industrial Biotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology

                Article
                10.3389/fbioe.2020.00959
                7513618
                33014998
                0f101d48-c280-4a90-bbe5-a81b624edef3
                Copyright © 2020 Guzik, Witko, Steinbüchel, Wojnarowska, Sołtysik and Wawak.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 15 June 2020
                : 24 July 2020
                Page count
                Figures: 5, Tables: 3, Equations: 1, References: 133, Pages: 15, Words: 11375
                Funding
                Funded by: Narodowe Centrum Badan i Rozwoju 10.13039/501100005632
                Funded by: Ministerstwo Nauki i Szkolnictwa Wyzszego 10.13039/501100004569
                Categories
                Bioengineering and Biotechnology
                Systematic Review

                polyhydroxyalkanoate,data mining,trends,composites,medicine,renewable production,polyhydroxyalkanoate (pha) synthesis,biotechnology

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