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      In vivo Distribution of Radioiodinated ACTH 1-2 4 in the Rat

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          Abstract

          After intravenous injection of <sup>125</sup>I-ACTH <sub>1-24</sub>into rats, the highest concentration of <sup>l25</sup>I was found in kidneys, adrenal, and liver. Addition of 5- and 30-fold excess unlabelled ACTH reduced the uptake of <sup>125</sup>I by 50 and 68%, respectively, indicating that the adrenal uptake was specific. Pretreatment with dexamethasone decreased the adrenal uptake of <sup>125</sup>I and caused adrenal atrophy. Chronic ACTH treatment increased the size of the adrenals, but did not affect the adrenal uptake of <sup>125</sup>I. These experiments demonstrate selective uptake of <sup>125</sup>I by the adrenals after administration of <sup>125</sup>I-ACTH<sub>1-24</sub>.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 15
          : 1
          : 44-54
          Affiliations
          Departments of Medicine and Biochemistry, Medical College of Ohio at Toledo, Ohio, USA; Departments of Pharmacology and Physiology, University of Illinois School of Medicine, Peoria, Ill., USA
          Article
          179433 Horm Res 1981;15:44–54
          10.1159/000179433
          6277758
          0f177130-73da-402f-80a0-9cbaaceb8f97
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 09 September 1980
          : 16 April 1981
          Page count
          Pages: 11
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Dexamethasone,ACTH distribution, 125I-ACTHU24,Adrenal uptake

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