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      In vivo Distribution of Radioiodinated ACTH 1-2 4 in the Rat

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          After intravenous injection of <sup>125</sup>I-ACTH <sub>1-24</sub>into rats, the highest concentration of <sup>l25</sup>I was found in kidneys, adrenal, and liver. Addition of 5- and 30-fold excess unlabelled ACTH reduced the uptake of <sup>125</sup>I by 50 and 68%, respectively, indicating that the adrenal uptake was specific. Pretreatment with dexamethasone decreased the adrenal uptake of <sup>125</sup>I and caused adrenal atrophy. Chronic ACTH treatment increased the size of the adrenals, but did not affect the adrenal uptake of <sup>125</sup>I. These experiments demonstrate selective uptake of <sup>125</sup>I by the adrenals after administration of <sup>125</sup>I-ACTH<sub>1-24</sub>.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          25 November 2008
          : 15
          : 1
          : 44-54
          Departments of Medicine and Biochemistry, Medical College of Ohio at Toledo, Ohio, USA; Departments of Pharmacology and Physiology, University of Illinois School of Medicine, Peoria, Ill., USA
          179433 Horm Res 1981;15:44–54
          © 1981 S. Karger AG, Basel

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          Pages: 11
          Original Paper


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