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      Is the Blood Flow in the Left Ventricle during the Isovolumic Relaxation Period a Useful Parameter of Left Ventricular Systolic and Early Diastolic Performance?


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          Left ventricular (LV) early diastolic performance is determined by LV behavior in the late systole to early diastole and may relate to the physical potential of patients. Isovolumic relaxation flow (IRF) velocity was obtained by continuous Doppler echocardiography in the left ventricle from the apex in 26 patients with atypical chest pain and 63 patients with coronary artery disease (CAD) with or without prior myocardial infarction (MI) who underwent cardiac catheterization. In each patient, a time constant of LV relaxation (τ) was calculated from the LV pressure waves obtained by a catheter-tipped micromanometer. The LV end-systolic volume index was measured using contrast left ventriculography. IRF velocity in patients having CAD with prior MI (24.8 ± 5.4 cm/s) was significantly less than in those with atypical chest pain (41.2 ± 9.6 cm/s). It was also significantly less than in patients having CAD without prior MI (37.3 ± 6.8 cm/s). IRF velocity significantly correlated with the time constant τ (r = –0.42, p < 0.001) and LV end-systolic volume index (r = –0.84, p < 0.001). This study indicates that IRF velocity obtained by continuous Doppler echocardiography in the left ventricle provides important information regarding LV systolic performance and early diastolic performance.

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          Author and article information

          S. Karger AG
          September 1999
          24 September 1999
          : 91
          : 3
          : 184-188
          aThird Department of Internal Medicine, Nagoya City University Medical School and bDepartment of Medicine, Nagoya City Sports and Rehabilitation Center, Nagoya, Japan
          6907 Cardiology 1999;91:184–188
          © 1999 S. Karger AG, Basel

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          Page count
          Figures: 4, Tables: 1, References: 17, Pages: 5
          Catheterization and Interventional Cardiology

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Continuous Doppler,Left ventricle,Isovolumic relaxation,Blood flow,Coronary artery disease


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