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      The complex world of WNT receptor signalling.

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      Nature reviews. Molecular cell biology
      Springer Science and Business Media LLC

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          Abstract

          30 years after the identification of WNTs, their signal transduction has become increasingly complex, with the discovery of more than 15 receptors and co-receptors in seven protein families. The recent discovery of three receptor classes for the R-spondin family of WNT agonists further adds to this complexity. What emerges is an intricate network of receptors that form higher-order ligand-receptor complexes routing downstream signalling. These are regulated both extracellularly by agonists such as R-spondin and intracellularly by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Dec 2012
          : 13
          : 12
          Affiliations
          [1 ] Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. C.Niehrs@imb-mainz.de
          Article
          nrm3470
          10.1038/nrm3470
          23151663
          0f4105d2-7084-4475-8955-87d6e2edbcf8
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