The insufficient innovation ability is the biggest bottleneck for the upgrading of creative industry in China. Thus, it is an important way to structure the good R&D innovative ecosystem around perfecting the innovative chain for improving the innovation ability of creative industry. This paper discusses the theoretical connotation of the R&D innovation ecosystem of creative industry, studies the spatial structure of the R&D innovation ecosystem, and proposes the fact that the innovative population of R&D innovation ecosystem in creative industry can be divided into original innovative population, technological innovation population, innovation service population, innovation input population, and system innovation population. The research on the demand, financing, and business model of R&D breakthrough innovation in China's industry cannot be separated from the analysis of the evolution stages of various industries, because different strategies need to be formulated at different stages of development, and it is very important to accurately grasp the stage of industrial development. By introducing logistic curve equation, the breakthrough innovation of industrial R&D is divided into four stages: incubation stage, growth stage, evolution stage, and maturity stage, and the different characteristics of different stages of industry development are analyzed. Taking the breakthrough innovation of R&D in industry as an example, this paper uses the logistic empirical model based on factor analysis to study it. The results show that the breakthrough innovation of R&D in industry has entered a maturity stage.