Albinism, an inherited condition from birth as a result of the lack of melanin pigment which usually changes the colour of the skin, hair and eyes, is usually greeted with resentment in most African communities. In Ghana, some communities and families consider it a misfortune to give birth to Albinos and hence, attempts are made to either kill them at birth or banish them from the community. They are constantly abused and ridiculed by the public with derogatory names and social tags that serve as a form of stigmatization. Evidently, it is clear that the discrimination against albinos in Ghana are underlain by religious and cultural beliefs. This article takes into perspective how religious beliefs and cultural values contribute to the plight of albinos in Ghana and further, discusses how the inculturation of human rights can help mitigate the violence that is perpetrated against persons with albinism.