Evaluation of a commercially available Zika virus IgM ELISA: specificity in focus.

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Abstract

Zika virus (ZIKV), an emerging arbovirus, has become the center of attention since it was linked to congenital abnormalities. Given the overlapping clinical picture of ZIKV disease with other infectious diseases and as an exigent public health matter, timely and reliable diagnosis of ZIKV infection is crucial. We evaluated the performance of a commercially available NS1-based ZIKV IgM ELISA. Our results showed suboptimal sensitivity within the first 5 days after onset while specificity remained robust.

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Journal

Journal ID (iso-abbrev): Diagn. Microbiol. Infect. Dis.

Title: Diagnostic microbiology and infectious disease

Publisher: Elsevier BV

ISSN (Electronic): 1879-0070

ISSN (Print): 0732-8893

Publication date (Electronic): Jul 2017

Volume: 88

Issue: 3

Affiliations

[1 ] Cadham Provincial Public Health Laboratory, Winnipeg, MB, Canada; Departments of Medical Microbiology & Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. Electronic address: kamran.kadkhoda@gov.mb.ca.

[2 ] Cadham Provincial Public Health Laboratory, Winnipeg, MB, Canada.

Article

Publisher Item ID: S0732-8893(17)30113-X

DOI: 10.1016/j.diagmicrobio.2017.04.002

PubMed ID: 28478111

SO-VID: 0f5a8ce1-46a2-4578-9d72-b9ba79a0e585

History

Keywords: Elisa,IgM,Specificity,Zika

Data availability:

Keywords: Elisa, IgM, Specificity, Zika

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