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      Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors

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          Abstract

          Background

          Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion in the resected material is used to differentiate between adenomas and carcinomas, which often results in the unnecessary removal of the adenomas. If nodules that may be follicular thyroid carcinomas are identified preoperatively, active surveillance of other nodules as adenomas is possible, which reduces the risk of surgical complications and the expenses incurred during medical treatment. Therefore, we aimed to identify biomarkers in the invasive subpopulation of follicular tumor cells.

          Methods

          We performed a spatial transcriptome analysis of a case of follicular thyroid carcinoma and examined the dynamics of CD74 expression in 36 cases.

          Results

          We identified a subpopulation in a region close to the invasive area, and this subpopulation expressed high levels of CD74. Immunohistochemically, CD74 was highly expressed in the invasive and peripheral areas of the tumor.

          Conclusions

          Although high CD74 expression has been reported in papillary and anaplastic thyroid carcinomas, it has not been analyzed in follicular thyroid carcinomas. Furthermore, the heterogeneity of CD74 expression in thyroid tumors has not yet been reported. The CD74-positive subpopulation identified in this study may be useful in predicting invasion of follicular thyroid carcinomas.

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          Most cited references27

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          2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.

          Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer.
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            Fast unfolding of communities in large networks

            Journal of Statistical Mechanics: Theory and Experiment, 2008(10), P10008
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              UMAP: Uniform Manifold Approximation and Projection

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                Author and article information

                Journal
                J Pathol Transl Med
                J Pathol Transl Med
                JPTM
                Journal of Pathology and Translational Medicine
                The Korean Society of Pathologists and the Korean Society for Cytopathology
                2383-7837
                2383-7845
                January 2024
                10 January 2024
                : 58
                : 1
                : 22-28
                Affiliations
                [1 ]Department of Pathology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
                [2 ]Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Hyogo, Japan
                [3 ]Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
                [4 ]Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan
                Author notes
                Corresponding Author: Ayana Suzuki, MHSc, Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, 8-2-35, Shimoyamate-dori, Chuo-ku, Kobe, Hyogo, 650-0011, Japan Tel: +81-78-371-3721, Fax: +81-78-371-3645, E-mail: suzuki01@ 123456kuma-h.or.jp
                Author information
                http://orcid.org/0000-0002-0827-1580
                http://orcid.org/0000-0002-5124-0026
                http://orcid.org/0000-0001-6134-3275
                http://orcid.org/0000-0002-4616-9608
                http://orcid.org/0009-0006-7636-5833
                http://orcid.org/0000-0002-4552-783X
                http://orcid.org/0000-0001-5558-7142
                http://orcid.org/0000-0001-8490-3650
                Article
                jptm-2023-11-21
                10.4132/jptm.2023.11.21
                10792275
                38229431
                0f66f7c2-ebdf-46e9-9397-8d2fb8ff2340
                © 2024 The Korean Society of Pathologists/The Korean Society for Cytopathology

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 27 October 2023
                : 21 November 2023
                : 21 November 2023
                Categories
                Original Article

                thyroid,follicular carcinoma,spatial transcriptome analysis,cd74,capsular invasion

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