The 3-5year epidemic cycle of dengue fever in Thailand makes it a major re-emerging public health problem resulting in being a burden in endemic areas. Although the Thai Ministry of Public Health adopted the WHO dengue control strategy, all dengue virus serotypes continue to circulate. Health officers and village health volunteers implement some intervention options but there is a need to ascertain most appropriate (or a combination of) interventions regarding the environment and contextual factors that may undermine the effectiveness of such interventions. This study aims to understand the dengue-climate relationship patterns at the district level in the southern region of Thailand from 2002 to 2018 by examining the statistical association between dengue incidence rate and eight environmental patterns, testing the hypothesis of equal incidence of these. Data on environmental variables and dengue reported cases in Nakhon Si Thammarat province situated in the south of Thailand from 2002 to 2018 were analysed to (1) detect the environmental factors that affect the risk of dengue infectious disease; to (2) determine if disease risk is increasing or decreasing over time; and to (3) identify the high-risk district areas for dengue cases that need to be targeted for interventions. To identify the predictors that have a high and significant impact on reported dengue infection, three steps of analysis were used. First, we used Partial Least Squares (PLS) Regression and Poisson Regression, a variant of the Generalized Linear Model (GLM). Negative co-efficient in correspondence with the PLS components suggests that sea-level pressure, wind speed, and pan evaporation are associated with dengue occurrence rate, while other variables were positively associated. Using the Akaike information criterion in the stepwise GLM, the filtered predictors were temperature, precipitation, cloudiness, and sea level pressure with the standardized coefficients showing that the most influential variable is cloud cover (three times more than temperature and precipitation). Also, dengue occurrence showed a constant negative response to the average increase in sea-level pressure values. In southern Thailand, the predictors that have been locally determined to drive dengue occurrence are temperature, rainfall, cloud cover, and sea-level pressure. These explanatory variables should have important future implications for epidemiological studies of mosquito-borne diseases, particularly at the district level. Predictive indicators guide effective and dynamic risk assessments, targeting pre-emptive interventions.