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      Alterations in Liver Blood Flow during Glycerol-Induced Acute Renal Failure in the Rat

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          Abstract

          Cardiac output and liver blood flow were measured using 15-µm diameter radioactive microspheres in anaesthetized male rats 12, 24 and 48 h and 7 days after induction of acute renal failure with glycerol. Plasma urea concentration was greatest in those rats studied 48 h after glycerol injection and at 7 days animals could be divided into ‘recovering’ and ‘azotemic’ on the basis of plasma urea levels. Cardiac output was significantly lower at 12 h than that found in control rats, but it was significantly greater than control values in azotemic animals at 48 h and in the ‘recovering’ group of rats at 7 days. Changes in cardiac output did not correlate with alterations in haematocrit. Liver blood flow showed a number of changes in the azotemic animals relative to the control rats; at 12 h it was significantly lower in the glycerol-treated rats whilst it was increased at 48 h and in both groups of animals at 7 days. When the proportion of cardiac output distributed to the liver was determined using 50-µm diameter microspheres, it was not significantly different from that determined using the smaller microspheres at 12 and 48 h after glycerol injection. This indicates that the results with the smaller microspheres were not distorted by incomplete trapping in the hepatic and splanchnic vascular beds. The implications of altered liver blood flow for drug metabolism in renal failure are discussed.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1980
          1980
          02 December 2008
          : 26
          : 5
          : 244-248
          Affiliations
          Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool
          Article
          181993 Nephron 1980;26:244–248
          10.1159/000181993
          7422052
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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