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      Molecular regulation of cardiac ryanodine receptor ion channel.

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      Cell calcium
      Elsevier BV

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          Abstract

          The release of Ca(2+) ions from intracellular stores is a key step in a wide variety of cellular functions. In striated muscle, the release of Ca(2+) from the sarcoplasmic reticulum (SR) leads to muscle contraction. Ca(2+) release occurs through large, high-conductance Ca(2+) release channels, also known as ryanodine receptors (RyRs) because they bind the plant alkaloid ryanodine with high affinity and specificity. The RyRs are isolated as 30S protein complexes comprised of four 560 kDa RyR2 subunits and four 12 kDa FK506 binding protein (FKBP12) subunits. Multiple endogenous effector molecules and posttranslational modifications regulate the RyRs. This review focuses on current research toward understanding the control of the isolated cardiac Ca(2+) release channel/ryanodine receptor (RyR2) by Ca(2+), calmodulin, thiol oxidation/reduction and nitrosylation, and protein phosphorylation.

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          Author and article information

          Journal
          Cell Calcium
          Cell calcium
          Elsevier BV
          0143-4160
          0143-4160
          Jun 2004
          : 35
          : 6
          Affiliations
          [1 ] Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA. meissner@med.unc.edu
          Article
          S0143416004000235
          10.1016/j.ceca.2004.01.015
          15110152
          0f944f4d-fa8c-4ed9-885f-3a9003e376a8
          History

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