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      Demonstration of Insulin-Like Growth Factors I, II and Heterogeneous Insulin-Like Growth Factor Binding Proteins in the Cyst Fluid of Patients with Craniopharyngioma

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          Insulin-like growth factor (IGF)-Π and its binding proteins were demonstrated to be present in human craniopharyngioma cyst fluid using gel filtration and ligand blot analyses. Immunoreactive IGF-II in 3 patients was found to be 274, 232 and 310 ng/ml after gel chromatography whereas IGF-I concentrations were 13, 8 and 15 ng/ml. The IGF-II levels were severalfold higher in cyst fluid than in spinal fluid while the IGF-I levels in both fluids did not differ significantly. The binding proteins showed high affinities for [<sup>125</sup>I]IGF-Π which could be displaced by unlabelled IGF-II. With the ligand blot analysis, [<sup>125</sup>I]IGF-II shows bands at 300, 175 and 46/43 kilodaltons probably representing IGF-II receptor and IGFBP-3. IGFBP-1 levels 17, 22 and 45 ng/ ml, respectively, were undetectable by ligand blot.

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          Author and article information

          S. Karger AG
          07 April 2008
          : 54
          : 3
          : 196-201
          Departments of aΕndocrinology and bNeurosurgery, Karolinska Hospital and Institute, Stockholm, Sweden
          125876 Neuroendocrinology 1991;54:196–201
          © 1991 S. Karger AG, Basel

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          Pages: 6
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