Ulrika A. Hänninen:
ORCID: http://orcid.org/0000-0003-1558-0450
Role: ConceptualizationRole: InvestigationRole: Project administrationRole: ValidationRole:
VisualizationRole: Writing – original draftRole: Writing – review & editing
Riku Katainen:
ORCID: http://orcid.org/0000-0003-4575-4239
Role: Data curationRole: Formal analysisRole: SoftwareRole: VisualizationRole: Writing
– original draftRole: Writing – review & editing
Tomas Tanskanen: Role: Formal analysisRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Roosa-Maria Plaketti: Role: Formal analysisRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Riku Laine: Role: Formal analysisRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Jiri Hamberg: Role: SoftwareRole: Writing – review & editing
Ari Ristimäki: Role: InvestigationRole: Writing – review & editing
Eero Pukkala: Role: ResourcesRole: Writing – review & editing
Minna Taipale: Role: InvestigationRole: Writing – review & editing
Jukka-Pekka Mecklin: Role: ConceptualizationRole: Writing – review & editing
Linda M. Forsström: Role: InvestigationRole: Writing – review & editing
Esa Pitkänen:
ORCID: http://orcid.org/0000-0002-9818-6370
Role: Data curationRole: SoftwareRole: Writing – review & editing
Kimmo Palin:
ORCID: http://orcid.org/0000-0002-4621-6128
Role: MethodologyRole: Writing – review & editing
Niko Välimäki: Role: Formal analysisRole: Writing – review & editing
Netta Mäkinen: Role: SupervisionRole: Writing – original draftRole: Writing – review & editing
Lauri A. Aaltonen: Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
SupervisionRole: Writing – review & editing
Adam Bass: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
9
March
2018
Publication date Collection:
March
2018
Volume: 14
Issue: 3
Electronic Location Identifier: e1007200
Affiliations
[1
]
Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki,
Helsinki, Finland
[2
]
Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki,
Finland
[3
]
Department of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki,
Helsinki, Finland
[4
]
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research,
Helsinki, Finland
[5
]
Faculty of Social Sciences, University of Tampere, Tampere, Finland
[6
]
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm,
Sweden
[7
]
Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
[8
]
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
Dana Farber Cancer Institute, UNITED STATES
Author notes
I have read the journal's policy and the authors of this manuscript have the following
competing interests: LAA has received a lecture fee from Roche Oy.
Author information
Article
Publisher ID:
PGENETICS-D-17-01877
DOI: 10.1371/journal.pgen.1007200
PMC ID: 5871010
PubMed ID: 29522538
SO-VID: 0fa4d263-2212-4109-9355-4b8d759f1883
Copyright © © 2018 Hänninen et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100002341, Academy of Finland;
Award ID: 250345
Award Recipient
:
Lauri A. Aaltonen
Funded by: funder-id http://dx.doi.org/10.13039/501100006383, Syöpäjärjestöt;
Award Recipient
:
Lauri A. Aaltonen
Funded by: funder-id http://dx.doi.org/10.13039/501100006306, Sigrid Juséliuksen Säätiö;
Award Recipient
:
Lauri A. Aaltonen
Funded by: funder-id http://dx.doi.org/10.13039/501100004012, Jane ja Aatos Erkon Säätiö;
Award Recipient
:
Lauri A. Aaltonen
Funded by: SYSCOL
Award Recipient
:
Lauri A. Aaltonen
Funded by: funder-id http://dx.doi.org/10.13039/501100002341, Academy of Finland;
Award ID: 295693
Award Recipient
:
Netta Mäkinen
Funded by: funder-id http://dx.doi.org/10.13039/501100002341, Academy of Finland;
Award ID: 287665
Award Recipient
:
Niko Välimäki
Funded by: funder-id http://dx.doi.org/10.13039/100008723, Suomen Lääketieteen Säätiö;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/501100003756, Biomedicum Helsinki-säätiö;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/501100004212, Päivikki ja Sakari Sohlbergin Säätiö;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/100007634, Ida Montinin Säätiö;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: The Gastroenterological Research Foundation
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/100010129, Maud Kuistilan Muistosäätiö;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/501100006383, Syöpäjärjestöt;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
Funded by: funder-id http://dx.doi.org/10.13039/501100009067, K. Albin Johanssons Stiftelse;
Award Recipient
:
ORCID: http://orcid.org/0000-0003-1558-0450
Ulrika A. Hänninen
This work was supported by grants from the Academy of Finland (Centre of Excellence
in Cancer Genetics Research 2012–2017, no. 250345), the Finnish Cancer Society, the
Sigrid Juselius Foundation, the Jane and Aatos Erkko Foundation, and SYSCOL (an EU
FP7 Collaborative Project, no. 258236). Personal grants were received from the Academy
of Finland (no. 295693 to NM and no. 287665 to NV). UAH received the following personal
grants for this work: the Finnish Medical Society “Duodecim”, Biomedicum Helsinki
Foundation, the Päivikki and Sakari Sohlberg Foundation, the Ida Montin Foundation,
the Gastroenterological Research Foundation, the Maud Kuistila Memorial Foundation,
Cancer Foundation Finland sr., and the K. Albin Johansson Foundation. The funders
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Nonsense Mutation
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Frameshift Mutation
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
Antigen-Presenting Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
Antigen-Presenting Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
Antigen-Presenting Cells
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Point Mutation
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Colorectal Cancer
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Somatic Mutation
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Adenocarcinomas