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      Cytochrome P450-CYP2 Family-Epoxygenase Role in Inflammation and Cancer.

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          Abstract

          Arachidonic acids are converted to eicosanoid mediators by different enzyme systems: cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) monooxygenase pathways (ω/ω-1-hydroxylases and epoxygenases). Of 57 putatively functional human CYPs, only about a dozen enzymes are responsible for xenobiotic metabolism. CYP2 family is the predominant epoxygenase isoform abundantly expressed in the endothelium, myocardium, and kidney in humans. Numerous studies have demonstrated the cardiovascular protective effects of CYP epoxygenases and eicosatrienoic acids ranging from vasodilation, antihypertensive, proangiogenesis, antiatherosclerosis, and cardiac protection. The roles of CYP2 family and their metabolites in inflammation and cancer biology have recently attracted great attention. Here, we review the recent progress on polymorphisms, distribution and function of CYP2 family, and their roles in inflammation and cancer.

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          Author and article information

          Journal
          Adv. Pharmacol.
          Advances in pharmacology (San Diego, Calif.)
          Elsevier BV
          1557-8925
          1054-3589
          2015
          : 74
          Affiliations
          [1 ] Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
          [2 ] Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: dwwang@tjh.tjmu.edu.cn.
          Article
          S1054-3589(15)00036-8
          10.1016/bs.apha.2015.04.005
          26233908
          0fb26e03-a14a-41b4-a023-250696767fe8
          History

          Arachidonic acids,Cancer,Cytochrome P450,Inflammation,CYP2
          Arachidonic acids, Cancer, Cytochrome P450, Inflammation, CYP2

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