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      Jaw metastasis as first presentation of lung adenocarcinoma. A case report Translated title: Metástasis mandibular como primera presentación de adenocarcinoma de pulmón. A propósito de un caso

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          Abstract

          ABSTRACT Metastatic disease of the oral cavity is rare and constitutes 1 % of all oral cavity malignancies. Lung cancer is the most common primary site metastasizing to the jaws, especially in man, and the mandible is more affected than the maxilla. We present the case of a 64 year-old-female patient who was admitted to hospital complaining of pain and swelling located to the left mandibular ascending ramus and angle, with 7 month duration. The first differential diagnosis was between primary malignances of the oral cavity, but the biopsy revealed a carcinoma of unknown origin. Further investigation revealed an advanced stage primary adenocarcinoma of the lung. Oral metastasis are usually evidence of a widespread disease and indicate a poor prognosis. As consequence, the treatment modalities for these patients are palliative in most cases. The clinical case of a 41-year-old male evaluated for a tumor in the attached gingiva with previous periodontal treatment and a history of kidney transplantation is described. Excisional biopsy was performed with a diagnosis of KS, which after completing the study confirmed disseminated iatrogenic-type KS requiring a change in immunosuppressive medication and 6 cycles of chemotherapy treatment with complete response.

          Translated abstract

          RESUMEN Las metástasis de la cavidad oral son lesiones raras y constituyen el 1 % de las enfermedades orales malignas. El cáncer de pulmón es el tumor primario que se disemina con más frecuencia en los maxilares, sobre todo en hombres, viéndose la mandíbula más afectada que la maxila. El caso que presentamos corresponde a una paciente de 64 años que acudió a nuestro hospital con una tumefacción del ángulo y de la rama ascendente mandibular de 7 meses de evolución. Inicialmente en el diagnóstico diferencial se incluyeron los tumores primarios de la cavidad oral, pero tras el resultado de la biopsia, se identificó un carcinoma de origen desconocido. El estudio de extensión puso de manifiesto un adenocarcinoma de pulmón en estadio avanzado. La presencia de metástasis orales es una evidencia de enfermedad diseminada y se asocian a un mal pronóstico, por lo cual los tratamientos para estos pacientes suelen ser paliativos.

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          Metastatic tumors to the jaws and oral cavity

          Cancer is a disease involving complex multiple sequential irreversible dysregulated processes showing metastasis that results in morbidity and mortality. Metastasis is a complex biological course that begins with detachment of tumor cells from the primary tumor, spreading into the distant tissues and/or organs, invading through the lymphovascular structures followed by their survival in the circulation. Metastatic tumors to the oro-facial region are uncommon and may occur in the oral soft tissues or jawbones. The clinical presentation of metastatic tumors can be variable, which may lead to erroneous diagnosis or may create diagnostic dilemma. Therefore, they should be considered in the differential diagnosis of inflammatory and reactive lesions that are common to the oral region. Most of the literature on oral metastases involves either single case reports or reviews of these reported cases from scattered geographical areas. Hence this present article is an attempt to provide a detailed review of pathogenesis, epidemiological details including clinical and radiographic presentations, microscopic features and treatment of metastatic tumors to the jaws and oral cavity.
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            Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution.

            Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients' clinical outcomes.
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              Metastasis to the Jawbones: A review of 453 cases

              The purpose of the present article was to review the characteristics of the jawbone metastases to analyze all variables. A relevant English Literature search in PubMed, Scopus, and Google Scholar was performed. All variables such as age, gender, primary and secondary tumor sites were analyzed. There were 453 metastatic cases. The male-to-female ratio was 1.2:1, and the mean age of the patients was 53.4 years. The lung was the most common primary site in men, and breast in women. The most common metastatic site was the mandible, and adenocarcinoma was the most frequent histological diagnosis. Metastases to the jaw bones occur in the advanced stages of a malignancy hence; a careful examination of patients with jaw bone lesions is strongly suggested. Dentists, as well as general physicians, should take into consideration the possible presence of jaw metastases in cases which present atypical symptoms, especially in patients with known malignant disease.
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                Author and article information

                Journal
                maxi
                Revista Española de Cirugía Oral y Maxilofacial
                Rev Esp Cirug Oral y Maxilofac
                Sociedad Española de Cirugía Oral y Maxilofacial y de Cabeza y Cuello (Madrid, Madrid, Spain )
                1130-0558
                2173-9161
                June 2021
                : 43
                : 2
                : 59-62
                Affiliations
                [3] Lisboa orgnameUniversidade Nova de Lisboa Portugal
                [2] Lisboa orgnameInstituto Português de Oncologia de Lisboa Francisco Gentil Portugal
                [1] Lisboa orgnameCentro Hospitalar Universitário Lisboa Central Portugal
                Article
                S1130-05582021000200059 S1130-0558(21)04300200059
                10.20986/recom.2021.1198/2020
                0fbafac3-3fc3-4c1f-a541-d7823f4e6b80

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 06 August 2020
                : 21 February 2021
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 10, Pages: 4
                Product

                SciELO Spain

                Categories
                Case Reports

                oral cancer,Metástasis mandibular,carcinoma de pulmón,adenocarcinoma de pulmón,cáncer oral,Mandibular metastasis,lung carcinoma,lung adenocarcinoma

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