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      Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing.

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          Abstract

          Dysregulation of pH is a feature of both tumor growth and tissue repair. In tumors, microenvironmental changes, like in lactate metabolism, lead to altered intra- and extracellular pH (pHi , pHe ) and vice versa. In wounds, barrier disruption results in extensive variations in pHe on the wound surface. It is known that altered extracellular proton concentrations have a major impact on cell turnover and migration as well as on the metabolic activity of cells involved in tumor spread and wound closure. The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pHe and transduce this signal to molecular intracellular pathways. Based on the current knowledge, we speculate on the role of proton-sensing GPCRs in wound healing and on their potential as mechanistic linkers of tumor growth and tissue repair.

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          Author and article information

          Journal
          Exp. Dermatol.
          Experimental dermatology
          Wiley
          1600-0625
          0906-6705
          February 2017
          : 26
          : 2
          Affiliations
          [1 ] Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.
          [2 ] Department of Internal Medicine III, Oncology, University Medical Center Regensburg, Regensburg, Germany.
          [3 ] Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.
          [4 ] Institute of Human Genetics, University of Cologne, Cologne, Germany.
          [5 ] Department of Otorhinolaryngology, University Medical Center Regensburg, Regensburg, Germany.
          Article
          10.1111/exd.13209
          27623507

          wounds, proton signalling, tissue repair, tumor metabolism

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