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      Duration of the Hypotensive Action of Nitroglycerin Ointment in Ambulatory Subjects Utilizing an Automatic Blood Pressure Recording Device

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      Cardiology

      S. Karger AG

      Nitroglycerin ointment

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          Abstract

          Nitroglycerin ointment (GTNO) is widely used in the treatment of angina pectoris. In order to use this agent effectively, its duration of action must be known. This study was designed to determine how long GTNO acts in the ambulatory subject. A portable blood pressure measuring device was used for this purpose. 10 normal subjects were studied on 3 consecutive days: day 1, control (c); day 2, placebo (P); day 3, GTNO. The dose of GTNO used was the amount required to produce a > 10-mm Hg fall in systolic blood pressure (BP). There was no significant difference in BP, heart rate (HR) or BP X HR product between C and P. On day 3 (GTNO), a fall in BP (p < 0.001) occurred when compared with C and P, and this change remained significantly different from C and P over a period of 7 h. Since these data suggest that the action of GTNO is maintained for at least 7 h, we conclude that its administration at this interval should be effective in the relief of angina pectoris.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1980
          1980
          31 October 2008
          : 66
          : 2
          : 102-110
          Affiliations
          Cardiology Section, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla.
          Article
          170855 Cardiology 1980;66:102–110
          10.1159/000170855
          6772302
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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