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Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.

Author(s): Michael J. Murray, K M Webberley

Publication date: 1989-11-30

Keywords: Aged, Cyclophosphamide, adverse effects, therapeutic use, Drug Interactions, Humans, Hyponatremia, chemically induced, Indomethacin, Male, Multiple Myeloma, drug therapy, Water Intoxication

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Abstract

We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide. We describe a possible drug interaction between these two drugs and recommend that they should only be used together with caution.

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PubMed ID:: 2616440

PMC ID:: 2429550

ScienceOpen disciplines: Chemistry

Keywords: Aged,Cyclophosphamide,adverse effects,therapeutic use,Drug Interactions,Humans,Hyponatremia,chemically induced,Indomethacin,Male,Multiple Myeloma,drug therapy,Water Intoxication

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ScienceOpen disciplines: Chemistry

Keywords: Aged, Cyclophosphamide, adverse effects, therapeutic use, Drug Interactions, Humans, Hyponatremia, chemically induced, Indomethacin, Male, Multiple Myeloma, drug therapy, Water Intoxication

Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin.

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