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      The evaluation of total mercury and arsenic in skin bleaching creams commonly used in Trinidad and Tobago and their potential risk to the people of the Caribbean

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          Abstract

          Background. Skin lightening is very popular among women and some men of the Caribbean, and its popularity appears to be growing. The lightening of skin colour is done to produce a lighter complexion which is believed to increase attractiveness, social standing and improves one’s potential of being successful.

          Design and Methods. Fifteen (15) common skin lightening creams found in pharmacies and cosmetic retailers throughout Trinidad and Tobago were evaluated for Mercury by Cold Vapor Atomic Absorption Spectrophotometry (CVAAS) and Arsenic by Hydride Generation Atomic Absorption Spectrophotometry (HGAAS). The results obtained were compared to global standards and previous research.

          Results. Fourteen (14) of the fifteen samples analysed contained Mercury in the range of 0.473 μg/g to 0.766 μg/g. One sample had a Mercury content of 14,507.74±490.75 μg/g which was over 14,000 times higher than the USFDA limit for mercury in cosmetics of 1 μg/g. All samples contained Arsenic in the range 1.016 μg/g to 6.612 μg/g, which exceeds the EU limit for cosmetics of 0 μg/g.

          Conclusions. All the samples analysed contained significant amounts of Mercury and Arsenic and none of them can be considered safe for prolonged human use. The samples that contained Mercury levels which were lower than the USFDA limit contained Arsenic levels which exceeded the EU standard of 0 μg/g in cosmetics. The popularity of these skin lightening creams in the Caribbean region places the population at elevated risk of chronic Mercury and Arsenic poisoning and possibly acute Mercury Poisoning.

          Significance for public health

          The lightening of one’s skin to achieve a more attractive and successful appearance has become part of the culture of the Caribbean, and the use of low priced skin lightening creams is widespread. The dangers posed by these products is unknown to many of its users and for those better informed, the use of so called Mercury free creams are preferred. This study revealed that none of the products investigated were Mercury free and introduces the lesser known danger of Arsenic exposure from these creams. This study therefore serves to increase awareness of the dangers of these products to public health, and provides valuable information to the medical practitioner that may allow a more timely and accurate diagnosis of potential Arsenic and Mercury poisoning.

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          Most cited references28

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          Public health. Arsenic epidemiology and drinking water standards.

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            Arsenic in drinking water and the prevalence of respiratory effects in West Bengal, India.

            A large population in West Bengal, India has been exposed to naturally occurring inorganic arsenic through their drinking water. A cross-sectional survey involving 7683 participants of all ages was conducted in an arsenic-affected region between April 1995 and March 1996. The main focus of the study was skin keratoses and pigmentation alterations, two characteristic signs of ingested inorganic arsenic. Strong exposure-response gradients were found for these skin lesions. The study also collected limited information concerning respiratory system signs and symptoms, which we report here because increasing evidence suggests that arsenic ingestion also causes pulmonary effects. Participants were clinically examined and interviewed, and the arsenic content in their current primary drinking water source was measured. There were few smokers and analyses were confined to non-smokers (N = 6864 participants). Among both males and females, the prevalence of cough, shortness of breath, and chest sounds (crepitations and/or rhonchi) in the lungs rose with increasing arsenic concentrations in drinking water. These respiratory effects were most pronounced in individuals with high arsenic water concentrations who also had skin lesions. Prevalence odds ratio (POR) estimates were markedly increased for participants with arsenic-induced skin lesions who also had high levels of arsenic in their current drinking water source (> or = 500 microg/l) compared with individuals who had normal skin and were exposed to low levels of arsenic (<50 microg/l). In participants with skin lesions, the age-adjusted POR estimates for cough were 7.8 for females (95% CI : 3.1-19.5) and 5.0 for males (95% CI : 2.6-9.9); for chest sounds POR for females was 9.6 (95% CI : 4.0-22.9) and for males 6.9 (95% CI : 3.1-15.0). The POR for shortness of breath in females was 23.2 (95% CI : 5.8-92.8) and in males 3.7 (95% CI : 1.3-10.6). These results add to evidence that long-term ingestion of inorganic arsenic can cause respiratory effects.
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              Diabetes mellitus associated with arsenic exposure in Bangladesh.

              The objective of this study was to assess whether arsenic exposure is a risk factor for diabetes mellitus as indicated in a few earlier studies. Arsenic in drinking water is known to occur in western Bangladesh, and in 1996, two of the authors conducted a survey of the prevalence of diabetes mellitus among 163 subjects with keratosis taken as exposed to arsenic and 854 unexposed individuals. Diabetes mellitus was determined by history of symptoms, previously diagnosed diabetes, glucosuria, and blood sugar level after glucose intake. The crude prevalence ratio for diabetes mellitus among keratotic subjects exposed to arsenic was 4.4 (95% confidence interval 2.5-7.7) and increased to 5.2 (95% confidence interval 2.5-10.5) after adjustment for age, sex, and body mass index. On the basis of a few earlier measurements of arsenic concentrations in drinking water by the authorities in Bangladesh and another 20 new ad hoc analyses, approximate time-weighted exposure levels to arsenic in drinking water could be estimated for each subject. Three time-weighted average exposure categories were created, i.e., less than 0.5, 0.5-1.0, and more than 1.0 mg/liter. For the unexposed subjects, the corresponding prevalence ratios were 1.0, 2.6, 3.9, and 8.8, representing a significant trend in risk (p < 0.001). The result corroborates earlier studies and suggests that arsenic exposure is a risk factor for diabetes mellitus.
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                Author and article information

                Journal
                J Public Health Res
                JPHR
                Journal of Public Health Research
                PAGEPress Publications, Pavia, Italy
                2279-9028
                2279-9036
                09 October 2017
                13 December 2017
                : 6
                : 3
                : 1097
                Affiliations
                Department of Chemistry, Faculty of Science and Technology, The University of the West Indies , St. Augustine, Trinidad and Tobago
                Author notes
                Department of Chemistry, Faculty of Science and Technology, The University of The West Indies, St. Augustine, Trinidad and Tobago. +1.868.662.2002 ext. 82282 terry.mohammed@ 123456sta.uwi.edu

                Contributions: TM, conceptualised, designed and coordinated the study, provided the samples, analysed the data and wrote the paper; EM, performed analysis of Mercury and Arsenic; SB, prepared samples for analysis and performed initial literature review.

                Article
                10.4081/jphr.2017.1097
                5736993
                0ffed4ac-aa1f-49d7-99f8-8e3f3c8ef321
                ©Copyright T. Mohammed et al., 2017

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 14 July 2017
                : 02 October 2017
                : 25 September 2017
                Page count
                Figures: 0, Tables: 2, Equations: 0, References: 40, Pages: 6
                Categories
                Article

                skin-lightening,skin-bleaching,mercury,arsenic,trinidad,caribbean

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