"Singapore Green": a new fluorescent dye for microarray and bioimaging applications.

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Abstract

We have synthesized Singapore Green (SG), a structural hybrid of Tokyo Green and Rhodamine 110. This new dye is a green light-emitting substitute for 7-aminocoumarin, a blue fluorescent dye widely used in enzymatic assays. SG-conjugated peptide substrates were successfully synthesized and used in microarray-based protease substrate profiling and live-cell imaging experiments.

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Journal

Journal ID (iso-abbrev): Org. Lett.

Title: Organic letters

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 1523-7052

ISSN (Print): 1523-7052

Publication date (Electronic): Jan 15 2009

Volume: 11

Issue: 2

Affiliations

[1 ] Department of Chemistry, NUS MedChem Program of the Office of Life Sciences, National University of Singapore, Singapore 117543.

Article

Publisher Item ID: 10.1021/ol802700w

DOI: 10.1021/ol802700w

PubMed ID: 19099491

SO-VID: 10018c45-4b84-4d84-9f4d-c6d65e5041a6

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