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      The essential role of T cells in multiple sclerosis: a reappraisal.

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      Biomedical journal

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          Abstract

          Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which destruction of myelin and nerve axons has been shown to be mediated by immune mechanisms. Although the focus of research has been traditionally on T cells as key mediators of the immunopathology, more recent efforts at understanding this complex disorder have been directed increasingly at other cellular and humoral elements of the immune response. This review is a reappraisal of the crucial role of T cells, in particular the CD4+ helper T-cell subset, in multiple sclerosis. Recent evidence is discussed underlining the predominant contribution of T-cell-associated genes to the genome-wide association study results of multiple sclerosis susceptibility, the loss of T-cell quiescence in the conversion from clinically isolated syndrome to clinically definite multiple sclerosis, and the fact that T cells represent the main target of effective immunomodulatory and immunosuppressive treatments in multiple sclerosis.

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          Author and article information

          Journal
          Biomed J
          Biomedical journal
          2320-2890
          2319-4170
          : 37
          : 2
          Affiliations
          [1 ] Clinical Neurology Research Group, Division of Clinical Neuroscience, University of Nottingham School of Medicine, Queen's Medical Centre, Nottingham, United Kingdom.
          Article
          BiomedJ_2014_37_2_34_128746
          10.4103/2319-4170.128746
          24732657
          10130a22-ad74-413c-8f0c-9d2ff4d97276
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