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      Normal T Lymphocyte Function in Patients with End-Stage Renal Disease Hemodialyzed with ‘High-Flux’ Polysulfone Membranes

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          Abstract

          T lymphocyte function was analyzed in patients hemodialyzed with ‘high-flux’ polysulfone membranes, which have been reported to improve the patients’ overall clinical condition and well-being. For comparison purposes, patients treated by the use of ‘low-flux’ cuprophane membranes were also studied. Peripheral blood white cell counts, numbers of lymphocytes as well as the numbers of T cells and their CD4 and CD8 subsets were within normal range in both patient groups. The absolute number of B cells was slightly decreased in cuprophane-membrane- but not polysulfone-membrane-treated patients. The proliferative response of T lymphocytes after stimulation with optimal concentration of phytohemagglutinin (PHA) was normal in patients treated with ‘high-flux’ membrane dialysis but significantly reduced in those treated with cuprophane membranes. The generation of interleukin-2 (IL-2) receptor on T lymphocytes after PHA stimulation was normal in the polysulfone-membrane-treated group and slightly impaired in the cuprophane-membrane-dialyzed patients. Production of both IL-2 and interleukin-1, as well as the natural killer cell activity, in patients treated by ‘high-flux’ membrane dialysis were also comparable to controls. The levels of serum β<sub>2</sub>-microglobulin were significantly elevated in patients-maintained on ‘high-flux’ dialysis membranes but did not reach the levels seen in patients dialyzed by cuprophane membranes. The pY microglobulin at levels seen in patients on cuprophane dialysis had no effects on activation and proliferation of control lymphocytes in vitro. These results suggest that impaired functional responses of T lymphocytes seen in end-stage disease patients on prolonged hemodialysis with cuprophane membranes are not seen in similar patients hemodialyzed with polysulfone membranes.

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          Author and article information

          Journal
          AJN
          Am J Nephrol
          10.1159/issn.0250-8095
          American Journal of Nephrology
          S. Karger AG
          0250-8095
          1421-9670
          1990
          1990
          28 October 2008
          : 10
          : 4
          : 276-282
          Affiliations
          aDepartments of Pathology and Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, N.J.; bRenal Dialysis Unit, Raritan Bay Medical Center, Perth Amboy, N.J., USA
          168120 Am J Nephrol 1990;10:276–282
          10.1159/000168120
          2240054
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Counts
          Pages: 7
          Categories
          Clinical Study

          Cardiovascular Medicine, Nephrology

          High flux, Hemodialysis, T lymphocytes

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