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      Brain RNA and Hypophysectomy; A Topographical Study

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      Neuroendocrinology

      S. Karger AG

      Hypophysectomy, Brain dissection, RNA

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          Abstract

          The present study was designed to localize the effect of hypophysectomy on brain RNA content at a topographical level. For this purpose, a brain dissection method, based on morphological dif-ferences between various brain areas, was developed. In these areas, total cell RNA was measured and expressed as the RNA/DNA ratio. The highest ratio was found in the cortex cerebri (ca. 2.15) and hippocampus (2.21), whereas cerebellum (0.42) and bulbus olfactorius (0.95) showed the lowest values. Hypophysectomy reduced the RNA content mainly of brain-stem structures (ca.–24%), i.e., the thalamus, hypothalamus, mesencephalon, and medulla oblongata. Nevertheless, a small but significant reduction was found in the rostral cortex. In view of previous studies, it is suggested that this disturbed RNA metabolism in brain-stem structures could have a bearing on the impaired avoidance performance of hypophysectomized rats.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1972
          1972
          19 March 2008
          : 9
          : 5
          : 285-296
          Affiliations
          Rudolf Magnus Institute for Pharmacology, and Laboratory for Physiological Chemistry, Medical Faculty, University of Utrecht, Utrecht
          Article
          122060 Neuroendocrinology 1972;9:285–296
          10.1159/000122060
          5030043
          © 1972 S. Karger AG, Basel

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          Page count
          Pages: 12
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