Brain RNA and Hypophysectomy; A Topographical Study

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Abstract

The present study was designed to localize the effect of hypophysectomy on brain RNA content at a topographical level. For this purpose, a brain dissection method, based on morphological dif-ferences between various brain areas, was developed. In these areas, total cell RNA was measured and expressed as the RNA/DNA ratio. The highest ratio was found in the cortex cerebri (ca. 2.15) and hippocampus (2.21), whereas cerebellum (0.42) and bulbus olfactorius (0.95) showed the lowest values. Hypophysectomy reduced the RNA content mainly of brain-stem structures (ca.–24%), i.e., the thalamus, hypothalamus, mesencephalon, and medulla oblongata. Nevertheless, a small but significant reduction was found in the rostral cortex. In view of previous studies, it is suggested that this disturbed RNA metabolism in brain-stem structures could have a bearing on the impaired avoidance performance of hypophysectomized rats.

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Author and article information

Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1972

Publication date (Print): 1972

Publication date (Electronic): 19 March 2008

Volume: 9

Issue: 5

Pages: 285-296

Affiliations

Rudolf Magnus Institute for Pharmacology, and Laboratory for Physiological Chemistry, Medical Faculty, University of Utrecht, Utrecht

Article

Publisher ID: 122060 Other ID: Neuroendocrinology 1972;9:285–296

DOI: 10.1159/000122060

PubMed ID: 5030043

SO-VID: 102137e3-c315-4c50-b527-3fec2db28c76

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 28 September 1971

Date accepted : 16 November 1971

Page count

Pages: 12

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