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      Inhibition contributes to orientation selectivity in visual cortex of cat.

      Nature
      Action Potentials, Animals, Cats, Cell Communication, Neurons, physiology, Orientation, Visual Cortex

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          Abstract

          Neurons in the visual cortex are selectively responsive to light or dark bars presented at particular orientations. On the basis of physiological data, this orientation selectivity is hypothesized as being due at least partially to intracortical inhibitory mechanisms. But this hypothesis has been challenged by intracellular recordings indicating that excitatory inputs themselves are orientation-selective, so inhibition may not contribute to the observed selectivity. Also, there is controversy about the presence of intracortical horizontal connections mediating inhibition for selectivity and about the theoretical validity of such inhibitory connections. Using cross-correlation analysis of the activities of two neurons recorded simultaneously, we find that inhibitory interactions exist between cells with somewhat different, but not orthogonal, orientation preferences. This suggests that intracortical horizontal inhibition operates between 'orientation columns' to sharpen the orientation tuning of cortical neurons.

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          Author and article information

          Journal
          3185710
          10.1038/335815a0

          Chemistry
          Action Potentials,Animals,Cats,Cell Communication,Neurons,physiology,Orientation,Visual Cortex
          Chemistry
          Action Potentials, Animals, Cats, Cell Communication, Neurons, physiology, Orientation, Visual Cortex

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